Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 6-Month Supply

US $76.78 Amazon price
65879 ratings

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Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age

Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed

Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact

Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days

Fragrance-free formula, waterproof after 24 hours of application

Advantage II Large Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Large Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Large Cat topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long. Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Cat is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia. That’s why Advantage II Large Cat makes applying treatment simple. This convenient, spot-on application goes on the back of your cat’s neck at the base of the skull. You’ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It goes on in seconds! It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II Large Cat is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects. Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat. For the ultimate convenience in care, Advantage II Large Cat is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Advantage II Large Cat is a trademark of Elanco or its affiliates.

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Top Reviews

  • Lesly
    2024-12-24T00:00:00
    I love it ! It worked just took a couple hours to fully stop my cats from itching. I had tried capstar and capaction and the fleas kept coming back and I don’t even let my cats outside so I tried this and it worked got rid of fleas and stopped my cats from itching. Im very happy I was nervous at first bc my cat is a senior cat and sensitive but it all worked out. Only downside is that it’s topical so even if you put it on their back between their shoulders it leaks sideways, so I put a shirt on them overnight till it dried up in a way. My younger cat licked it and started salivating like crazy that’s why I suggest you put on a shirt on them if you apply it because I’m sure it’s not safe for them to ingest I had to rinse his mouth out it was very scary but he is fine! Make sure you always stay around your pet to watch for any reactions and to make sure they don’t lick it! Great quality and came a couple hours after I placed the order.
  • Roman
    2024-12-01T00:00:00
    I’ve used this product multiple times for my cats, and it works perfectly every single time. It’s highly effective, easy to use, and has never caused any issues for my pets. I’ve been consistently impressed with the results, and it has become my go-to solution for keeping my cats flea-free. I’m incredibly satisfied and would recommend it to anyone looking for a reliable flea treatment.
  • Amazon Customer
    2025-01-03T00:00:00
    Best Flea protection by far! Since using Advantage II, the fleas are gone! Works fast in just 24 hours our cat was scratching a whole lot less and a few days later almost all the fleas were gone! Our family has been using this for a couple months now and our cat is flea free and happy again. I would highly recommend Advantage II. Thanks so much for making a great flea protection that truly works!
  • Carpenter
    2025-01-03T00:00:00
    Doesn't seem to be completely effective, although nothing nowadays is. Fleas appear to have developed a resistance to everything available including spray pesticides.
  • Charles
    2025-01-02T00:00:00
    Fleas are hard to eliminate. They breed quickly and often. Some are resistant to current insecticides. This product works well on our cats and it is easy to apply. You will need to apply this monthly to maintain consistent pest control.
  • Jeanette V.
    2024-11-30T00:00:00
    I've tried other flea medicine that hasn't worked and have had to wait weeks before using a better treatment. This is the heavy duty stuff that will annihilate a flea infestation. My cats hate the smell of it, but they don't seem to get any skin irritation. Great product, worth the money.
  • Amazon Customer
    2024-12-01T00:00:00
    My cat had been on a less expensive, once a month flea treatment for several years. However it seemed to lose its effectiveness. He lives inside 70 % of the time, but he started having a flea issue, So I tried this instead and he is very happy. He has not had any issues with fleas since I started this 5 months ago. It is easy to apply. Plus he is 14 pounds. So he’s a big boy and a lot of flea medicine is meant for a cat under 10 pounds.
  • DONNA J. TODD
    2024-08-04T00:00:00
    The first time I used this product on my two large cats, it was apparent that it worked quickly. One of our cats had chewed off his fur on his belly and legs before treatment and his hair began to grow back within a few days of treatment. Unfortunately, both cats began scratching again after 10 days. Since this product allows reapplication every week for up to 4 times, I simply reapplied and the product lasted 15 days before the treatment stopped working. I have now treated them for a third time and will wait to see how long the treatment is effective. I also vacuum almost daily, spray with Vet's Best Home Spray, and check the cats daily with a flea comb. I found live fleas on both cats at the end of the 10 day and the 15 day treatments. Mine are inside only cats and the only pets. Since I used the Elanco Advantage II, I have ordered the Bayer Advantage II to see if that makes a difference in the length of effectiveness. I found application to be very easy and my cats have had no adverse reaction to the medication. I just wish it worked longer than it does. Treatments were done exactly as directed.